[HTML][HTML] Receptor for interleukin 13: interaction with interleukin 4 by a mechanism that does not involve the common γ chain shared by receptors for interleukins 2, 4, 7 …
NI Obiri, W Debinski, WJ Leonard, RK Puri - Journal of Biological Chemistry, 1995 - ASBMB
Interleukin 13 (IL-13) shares many biological properties with IL-4, and although the receptor
for IL-4 (IL-4R) has been characterized, the expression and structure of IL-13 receptor are
unknown. We report here that human renal cell carcinoma (RCC) cells express large
numbers of functional IL-13R. Human B lymphocytes and monocytes expressed a very small
number of IL-13R, while resting or activated human T cells expressed little or no IL-13R. IL-4
did not compete for IL-13 binding, while IL-13 competed for IL-4 binding, even though IL-4R …
for IL-4 (IL-4R) has been characterized, the expression and structure of IL-13 receptor are
unknown. We report here that human renal cell carcinoma (RCC) cells express large
numbers of functional IL-13R. Human B lymphocytes and monocytes expressed a very small
number of IL-13R, while resting or activated human T cells expressed little or no IL-13R. IL-4
did not compete for IL-13 binding, while IL-13 competed for IL-4 binding, even though IL-4R …