[HTML][HTML] Reparative T lymphocytes in organ injury

FR D'Alessio, JT Kurzhagen… - The Journal of clinical …, 2019 - Am Soc Clin Investig
FR D'Alessio, JT Kurzhagen, H Rabb
The Journal of clinical investigation, 2019Am Soc Clin Investig
Acute organ injuries such as acute cerebrovascular accidents, myocardial infarction, acute
kidney injury, acute lung injury, and others are among the leading causes of death
worldwide. Dysregulated or insufficient organ repair mechanisms limit restoration of
homeostasis and contribute to chronic organ failure. Studies reveal that both humans and
mice harness potent non-stem cells that are capable of directly or indirectly promoting tissue
repair. Specific populations of T lymphocytes have emerged as important reparative cells …
Acute organ injuries such as acute cerebrovascular accidents, myocardial infarction, acute kidney injury, acute lung injury, and others are among the leading causes of death worldwide. Dysregulated or insufficient organ repair mechanisms limit restoration of homeostasis and contribute to chronic organ failure. Studies reveal that both humans and mice harness potent non-stem cells that are capable of directly or indirectly promoting tissue repair. Specific populations of T lymphocytes have emerged as important reparative cells with context-specific actions. These T cells can resolve inflammation and secrete reparative cytokines and growth factors as well as interact with other immune and stromal cells to promote the complex and active process of tissue repair. This Review focuses on the major populations of T lymphocytes known to mediate tissue repair, their reparative mechanisms, and the diseases in which they have been implicated. Elucidating and harnessing the mechanisms that promote the reparative functions of these T cells could greatly improve organ dysfunction after acute injury.
The Journal of Clinical Investigation