Antibodies to myelin basic protein are associated with cognitive decline after stroke
B lymphocytes cause post-stroke cognitive decline in mice. We therefore evaluated the
association between autoantibodies and post-stroke cognitive decline in a prospectively
collected human cohort. The mini-mental state exam (MMSE) was administered 30, 90, 180,
and 365 days after stroke. Antibody titers to myelin basic protein (MBP), proteolipid protein,
and several non-specific proteins were determined. Among 58 subjects with initial MMSE≥
20 and at least 2 MMSE examinations in the year after stroke, cognitive decline (MMSE …
association between autoantibodies and post-stroke cognitive decline in a prospectively
collected human cohort. The mini-mental state exam (MMSE) was administered 30, 90, 180,
and 365 days after stroke. Antibody titers to myelin basic protein (MBP), proteolipid protein,
and several non-specific proteins were determined. Among 58 subjects with initial MMSE≥
20 and at least 2 MMSE examinations in the year after stroke, cognitive decline (MMSE …