[HTML][HTML] Inhibition of ICE slows ALS in mice
RM Friedlander, RH Brown, V Gagliardini, J Wang… - Nature, 1997 - nature.com
Nature, 1997•nature.com
Amyotrophic lateral sclerosis (ALS) is a progressive age-dependent disease involving
degeneration of motor neurons in the brain, brainstem and spinal cord. ALS is universally
fatal, with the median survival of patients being five years from diagnosis. In a transgenic
mouse model of ALS, we now show that a dominant negative inhibitor of a cell-death gene,
the interleukin-1β-converting enzyme (ICE), significantly slows the symptomatic progression
of ALS.
degeneration of motor neurons in the brain, brainstem and spinal cord. ALS is universally
fatal, with the median survival of patients being five years from diagnosis. In a transgenic
mouse model of ALS, we now show that a dominant negative inhibitor of a cell-death gene,
the interleukin-1β-converting enzyme (ICE), significantly slows the symptomatic progression
of ALS.
Abstract
Amyotrophic lateral sclerosis (ALS) is a progressive age-dependent disease involving degeneration of motor neurons in the brain, brainstem and spinal cord. ALS is universally fatal, with the median survival of patients being five years from diagnosis. In a transgenic mouse model of ALS, we now show that a dominant negative inhibitor of a cell-death gene, the interleukin-1β-converting enzyme (ICE), significantly slows the symptomatic progression of ALS.
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