[HTML][HTML] Distinct serum biosignatures are associated with different tuberculosis treatment outcomes

K Ronacher, NN Chegou, L Kleynhans, JFD Siawaya… - Tuberculosis, 2019 - Elsevier
Biomarkers for TB treatment response and outcome are needed. This study characterize
changes in immune profiles during TB treatment, define biosignatures associated with
treatment outcomes, and explore the feasibility of predictive models for relapse. Seventy-two
markers were measured by multiplex cytokine array in serum samples from 78 cured, 12
relapsed and 15 failed treatment patients from South Africa before and during therapy for
pulmonary TB. Promising biosignatures were evaluated in a second cohort from …