The Supplementary Information of our original Letter (https://doi. org/10.1038/nature11003) and the Addendum published on 28 November 2012 (https://doi. org/10.1038/nature11735; hereafter referred to as ‘first Addendum’) contain all of the data used for our analyses. These data include normalized activity (growth inhibition) responses for every cell line at each dose for all 24 of the compounds and drugs tested. These activity values were calculated from replicated data points extracted from one or more experimental assay plates, and normalized using treated and untreated controls from the same plates; as detailed in the original Letter (see the original Supplementary Information 2, page 10), and in the first Addendum. In subsequent correspondence, readers expressed an interest in reproducing our experimental pre-processing, so we shared with them the raw Cell Titer Glo (CTG) data values from each experimental well. These data are now provided as a reference for future readers.