[HTML][HTML] E4BP4 is an insulin-induced stabilizer of nuclear SREBP-1c and promotes SREBP-1c-mediated lipogenesis [S]
Upon food intake, insulin stimulates de novo lipogenesis (DNL) in hepatocytes via the AKT-
mTORC1-sterol regulatory element-binding protein (SREBP)-1c pathway. How insulin
maintains the maximal SREBP-1c activities during the entire feeding state remains elusive.
We previously reported that insulin induced b-ZIP transcription factor, E4-binding protein 4
(E4BP4), in hepatocytes. In the current study, we show that insulin injection increases
hepatic E4bp4 expression by activating the AKT-mTORC1-SREBP-1c pathway in …
mTORC1-sterol regulatory element-binding protein (SREBP)-1c pathway. How insulin
maintains the maximal SREBP-1c activities during the entire feeding state remains elusive.
We previously reported that insulin induced b-ZIP transcription factor, E4-binding protein 4
(E4BP4), in hepatocytes. In the current study, we show that insulin injection increases
hepatic E4bp4 expression by activating the AKT-mTORC1-SREBP-1c pathway in …