[HTML][HTML] Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases

K Nagata, K Ohashi, T Nakano, H Arita, C Zong… - Journal of Biological …, 1996 - ASBMB
Axl, Sky, and Mer, members of an Axl/Sky receptor tyrosine kinase subfamily, are typified by
the cell adhesion molecule-related extracellular domain. The product of growth arrest-
specific gene 6 (Gas6), structurally homologous to the anticoagulant protein S, was recently
identified as the ligand for Axl and Sky, but the ligand for Mer remained unknown. We have
now obtained evidence that Gas6 can also function as a ligand for Mer. Co-precipitation
analysis, using soluble receptors of Axl, Sky, and Mer (Axl-Fc, Sky-Fc, and Mer-Fc) …