[HTML][HTML] Novel interaction of class IIb histone deacetylase 6 (HDAC6) with class IIa HDAC9 controls gonadotropin releasing hormone (GnRH) neuronal cell survival …
The impact of histone deacetylases (HDACs) in the control of gonadotropin releasing
hormone (GnRH) neuronal development is unknown. We identified an increase in many
HDACs in GT1-7 (differentiated) compared with NLT (undifferentiated) GnRH neuronal cell
lines. Increased HDAC9 mRNA and protein and specific deacetylase activity in GT1-7 cells
suggested a functional role. Introduction of HDAC9 in NLT cells protected from serum
withdrawal induced apoptosis and impaired basal neuronal cell movement. Conversely …
hormone (GnRH) neuronal development is unknown. We identified an increase in many
HDACs in GT1-7 (differentiated) compared with NLT (undifferentiated) GnRH neuronal cell
lines. Increased HDAC9 mRNA and protein and specific deacetylase activity in GT1-7 cells
suggested a functional role. Introduction of HDAC9 in NLT cells protected from serum
withdrawal induced apoptosis and impaired basal neuronal cell movement. Conversely …