[HTML][HTML] Mechanism for nucleocytoplasmic shuttling of histone deacetylase 7

HY Kao, A Verdel, CC Tsai, C Simon, H Juguilon… - Journal of Biological …, 2001 - ASBMB
Here we show that HDAC7, a member of the class II histone deacetylases, specifically
targets several members of myocyte enhancer factors, MEF2A,-2C, and-2D, and inhibits
their transcriptional activity. Furthermore, we demonstrate that DNA-bound MEF2C is
capable of recruiting HDAC7, demonstrating that the HDAC7-dependent repression of
transcription is not due to the inhibition of the MEF2 DNA binding activity. The data also
suggest that the promoter bound MEF2 is potentially capable of remodeling adjacent …