The anticancer drug cis-diammindichloroplatin (CDDP, cisplatin) causes severe side effects
like peripheral sensitive neuropathy. The toxicity of CDDP has been linked to changes in
intracellular calcium homeostasis ([Ca2+] i). Voltage activated calcium channel currents (ICa
(V)) are important for the regulation of [Ca2+] i; therefore, this study was designed to
examine the effect of CDDP on ICa (V) in comparison to voltage activated potassium (IK (V))
and sodium (INa (V)) channel currents using the whole cell patch clamp method on dorsal …