DNA damage recognition and nucleotide excision repair in mammalian cells

RD Wood, SJ Araujo, RR Ariza… - Cold Spring Harbor …, 2000 - symposium.cshlp.org
RD Wood, SJ Araujo, RR Ariza, DP Batty, M Biggerstaff, E Evans, PH Gaillard, D Gunz…
Cold Spring Harbor symposia on quantitative biology, 2000symposium.cshlp.org
XPA Rad14 rhp14 Xpac binds DNA within preincision complex XPC Rad4 CAA94702
Mus210 preferentially binds damaged DNA during initial recognition HR23B Rad23 rhp23
Rad23 preferentially binds damaged DNA during initial recognition XPG (ERCC5) Rad2
rad13 Mus201 structure-specific nuclease for 5 incision XPF (ERCC4) Rad1 rad16 Mei9
components of structure-specific nuclease for the 5 incision ERCC1 Rad10 swi10 Ercc1
components of structure-specific nuclease for the 5 incision XPB (ERCC3) Ssl2 (Rad25) …
XPA Rad14 rhp14 Xpac binds DNA within preincision complex XPC Rad4 CAA94702 Mus210 preferentially binds damaged DNA during initial recognition HR23B Rad23 rhp23 Rad23 preferentially binds damaged DNA during initial recognition XPG (ERCC5) Rad2 rad13 Mus201 structure-specific nuclease for 5 incision XPF (ERCC4) Rad1 rad16 Mei9 components of structure-specific nuclease for the 5 incision ERCC1 Rad10 swi10 Ercc1 components of structure-specific nuclease for the 5 incision XPB (ERCC3) Ssl2 (Rad25) rhp25 hay (haywire) 3-5 DNA helicase subunit of TFIIH XPD (ERCC2) Rad3 rad15 Xpd 5-3 DNA helicase subunit of TFIIH p44 Ssl1 SPCC1682 TFIIH subunits; minimally a 6-subunit form of TFIIH opens the DNA around a lesion in the preincision complex to create a bubble structure for cleavage by the structure-specific nucleases p62 Tfb1 same as for p44 above p55 Tfb2 SPBC13G1. 13 same as for p44 above (MAT1) Tfb3 Mat1 same as for p44 above p34 Tfb4 same as for p44 above RPAp70 RFA1 ssb1 (rad11) RpA-70 heterotrimer that binds to single-stranded DNA within the preincision intermediate; modulates structure-specific nuclease activities
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