T-cell cross-reactivity is essential for effective immune surveillance but has also been
implicated as a pathway to autoimmunity. Previous studies have demonstrated that T-cell
receptors (TCRs) that focus on a minimal motif within the peptide are able to facilitate a high
level of T-cell cross-reactivity. However, the structural database shows that most TCRs
exhibit less focused antigen binding involving contact with more peptide residues. To further
explore the structural features that allow the clonally expressed TCR to functionally engage …