[HTML][HTML] Physical coupling supports the local Ca2+ transfer between sarcoplasmic reticulum subdomains and the mitochondria in heart muscle
C García-Pérez, G Hajnóczky, G Csordás - Journal of Biological Chemistry, 2008 - ASBMB
In many cell types, transfer of Ca 2+ released via ryanodine receptors (RyR) to the
mitochondrial matrix is locally supported by high [Ca 2+] microdomains at close contacts
between the sarcoplasmic reticulum (SR) and mitochondria. Here we studied whether the
close contacts were secured via direct physical coupling in cardiac muscle using isolated rat
heart mitochondria (RHMs)." Immuno-organelle chemistry" revealed RyR2 and
calsequestrin-positive SR particles associated with mitochondria in both crude and Percoll …
mitochondrial matrix is locally supported by high [Ca 2+] microdomains at close contacts
between the sarcoplasmic reticulum (SR) and mitochondria. Here we studied whether the
close contacts were secured via direct physical coupling in cardiac muscle using isolated rat
heart mitochondria (RHMs)." Immuno-organelle chemistry" revealed RyR2 and
calsequestrin-positive SR particles associated with mitochondria in both crude and Percoll …