[HTML][HTML] Recipient HO-1 inducibility is essential for posttransplant hepatic HO-1 expression and graft protection: From bench-to-bedside
S Kageyama, H Hirao, K Nakamura, B Ke… - American Journal of …, 2019 - Elsevier
By documenting potent antioxidative and anti-inflammatory functions, preclinical studies
encourage heme oxygenase-1 (HO-1)-inducing regimens in clinical orthotopic liver
transplantation (OLT). We aimed to determine the importance of recipient-derived HO-1 in
murine and human OLTs. Hepatic biopsies from 51 OLT patients were screened for HO-1
expression (Western blots) prior to put-in (basal) and post reperfusion (stressed) and
correlated with the hepatocellular function. In parallel, livers from HO-1 proficient mice (WT; …
encourage heme oxygenase-1 (HO-1)-inducing regimens in clinical orthotopic liver
transplantation (OLT). We aimed to determine the importance of recipient-derived HO-1 in
murine and human OLTs. Hepatic biopsies from 51 OLT patients were screened for HO-1
expression (Western blots) prior to put-in (basal) and post reperfusion (stressed) and
correlated with the hepatocellular function. In parallel, livers from HO-1 proficient mice (WT; …