Recipient T cell TIM-3 and hepatocyte galectin-9 signalling protects mouse liver transplants against ischemia-reperfusion injury
Y Liu, H Ji, Y Zhang, X Shen, F Gao, X He, GA Li… - Journal of …, 2015 - Elsevier
Background & Aims By binding to T cell immunoglobulin mucin-3 (TIM-3) on activated Th1
cells, galectin-9 (Gal-9) negatively regulates Th1-type alloimmunity. Although T cells
contribute to hepatic ischemia-reperfusion injury (IRI), it is unknown whether negative T cell-
dependent TIM-3 co-stimulation may rescue IR-stressed orthotopic liver transplants from
innate immunity-driven inflammation. Methods We used wild type (WT) and TIM-3 transgenic
(Tg) mice (C57BL/6) as liver donors and recipients in a clinically-relevant model of hepatic …
cells, galectin-9 (Gal-9) negatively regulates Th1-type alloimmunity. Although T cells
contribute to hepatic ischemia-reperfusion injury (IRI), it is unknown whether negative T cell-
dependent TIM-3 co-stimulation may rescue IR-stressed orthotopic liver transplants from
innate immunity-driven inflammation. Methods We used wild type (WT) and TIM-3 transgenic
(Tg) mice (C57BL/6) as liver donors and recipients in a clinically-relevant model of hepatic …