Mechanism of cell death during warm hepatic ischemia–reperfusion in rats: apoptosis or necrosis?
JS Gujral, TJ Bucci, A Farhood, H Jaeschke - Hepatology, 2001 - journals.lww.com
Reperfusion injury can cause liver dysfunction after cold storage and warm ischemia.
Recently it has been suggested that more than 50% of hepatocytes and sinusoidal
endothelial cells (SEC) are undergoing apoptosis during the first 24 hours of reperfusion.
The aim of our study was to quantify apoptotic and necrotic hepatocytes and apoptotic SEC
after 60 or 120 minutes of warm, partial no–flow ischemia and 0 to 24 hours reperfusion in
male SD rats. Apoptotic cells were identified by TUNEL assay in combination with …
Recently it has been suggested that more than 50% of hepatocytes and sinusoidal
endothelial cells (SEC) are undergoing apoptosis during the first 24 hours of reperfusion.
The aim of our study was to quantify apoptotic and necrotic hepatocytes and apoptotic SEC
after 60 or 120 minutes of warm, partial no–flow ischemia and 0 to 24 hours reperfusion in
male SD rats. Apoptotic cells were identified by TUNEL assay in combination with …