[HTML][HTML] Oxidative stress is increased in primary and post− polycythemia vera myelofibrosis

C Vener, C Novembrino, FB Catena… - Experimental …, 2010 - Elsevier
OBJECTIVE: To determine if increased cell turnover in chronic myeloproliferative disorders
can lead to hyperhomocysteinemia as a result of folate and/or cobalamin depletion, and
contribute to oxidative stress. MATERIALS AND METHODS: The clinical role of oxidative
stress was investigated by measuring reactive oxygen species (ROS), total antioxidant
capacity (TAC), and total homocysteine (tHcy), folate, cobalamin, and holotranscobalamin
(HoloTC) levels in 51 chronic myeloproliferative disorders patients (male-to-female ratio: 1.1; …