Biogenesis and function of the NGF/TrkA signaling endosome
MC Marlin, G Li - International review of cell and molecular biology, 2015 - Elsevier
Target-derived neurotrophin nerve growth factor (NGF) and its receptor TrkA are well known
for retrograde signaling to promote survival and innervation of sympathetic and sensory
neurons. In recent years, the signaling endosome model has been used to describe the
sustained NGF/TrkA retrograde signaling as a process of endocytosis and retrograde
transport of NGF/TrkA-containing endosomes from the axon terminal to the cell body for
activation of NGF-inducible gene expression responsible for neuronal survival and …
for retrograde signaling to promote survival and innervation of sympathetic and sensory
neurons. In recent years, the signaling endosome model has been used to describe the
sustained NGF/TrkA retrograde signaling as a process of endocytosis and retrograde
transport of NGF/TrkA-containing endosomes from the axon terminal to the cell body for
activation of NGF-inducible gene expression responsible for neuronal survival and …