Dysbalance in sympathetic neurotransmitter release and action in cirrhotic rats: impact of exogenous neuropeptide Y
P Dietrich, L Moleda, F Kees, M Müller, RH Straub… - Journal of …, 2013 - Elsevier
BACKGROUND & AIMS: Splanchnic vasodilation is an essential disturbance in portal
hypertension. Increased systemic sympathetic nerve activity is well known, but potential
corresponding vascular desensitization is incompletely characterized. Release of
splanchnic sympathetic neurotransmitters noradrenaline (NA) and co-transmitter
neuropeptide Y (NPY) remains to be elucidated. Finally, the effects of exogenous NPY on
these mechanisms are unexplored. METHODS: Portal vein ligated cirrhotic, and control rats …
hypertension. Increased systemic sympathetic nerve activity is well known, but potential
corresponding vascular desensitization is incompletely characterized. Release of
splanchnic sympathetic neurotransmitters noradrenaline (NA) and co-transmitter
neuropeptide Y (NPY) remains to be elucidated. Finally, the effects of exogenous NPY on
these mechanisms are unexplored. METHODS: Portal vein ligated cirrhotic, and control rats …