Hybrid neurofibroma/schwannoma is overrepresented among schwannomatosis and neurofibromatosis patients

A Harder, M Wesemann, C Hagel… - The American journal …, 2012 - journals.lww.com
We analyzed the histologic features of peripheral nerve sheath tumors occurring in 14
patients with schwannomatosis. Among a total of 31 tumors, 19 tumors (61%) showed
schwannoma-like nodules within a neurofibroma-like tumor, corresponding to hybrid
neurofibroma/schwannoma. At least 1 hybrid tumor occurred in 10 of 14 (71%)
schwannomatosis patients. We then retrieved cases of hybrid tumors without documented
relation to schwannomatosis from our database and identified 41 tumors arising in 23 …