[HTML][HTML] The TRPV4 cation channel mediates stretch-evoked Ca2+ influx and ATP release in primary urothelial cell cultures
T Mochizuki, T Sokabe, I Araki, K Fujishita… - Journal of Biological …, 2009 - ASBMB
Transient receptor potential channels have recently been implicated in physiological
functions in a urogenital system. In this study, we investigated the role of transient receptor
potential vanilloid 4 (TRPV4) channels in a stretch sensing mechanism in mouse primary
urothelial cell cultures. The selective TRPV4 agonist, 4α-phorbol 12, 13-didecanoate (4α-
PDD) evoked Ca 2+ influx in wild-type (WT) urothelial cells, but not in TRPV4-deficient
(TRPV4KO) cells. We established a cell-stretch system to investigate stretch-evoked …
functions in a urogenital system. In this study, we investigated the role of transient receptor
potential vanilloid 4 (TRPV4) channels in a stretch sensing mechanism in mouse primary
urothelial cell cultures. The selective TRPV4 agonist, 4α-phorbol 12, 13-didecanoate (4α-
PDD) evoked Ca 2+ influx in wild-type (WT) urothelial cells, but not in TRPV4-deficient
(TRPV4KO) cells. We established a cell-stretch system to investigate stretch-evoked …