[HTML][HTML] Lymphotoxin-beta receptor blockade induces inflammation and fibrosis in tolerized cardiac allografts

Y Nakayama, JS Bromberg - American journal of transplantation, 2012 - Elsevier
The lymphotoxin system (LT) regulates interactions between lymphocytes and stromal cells
to maintain lymphoid microenvironmental homeostasis. Soluble LT beta-receptor-Ig
(LTβRIg) blocks lymphocyte LTα1β2-stromal cell LTβR signaling. In a murine cardiac
allograft model, LTbRIg treatment reversed the tolerance induced by anti-CD40L antibody
leading to graft inflammation and fibrosis. LTβRIg treatment decreased PD-L1 expression by
blood endothelial cells, and decreased VCAM-1 while increasing CXCL1, CXCL2, CXCL12 …