Skeletal muscle regeneration is an efficient stem cell-based repair system that ensures
healthy musculature. For this repair system to function continuously throughout life, muscle
stem cells must contribute to the process of myofiber repair as well as repopulation of the
stem cell niche. The decision made by the muscle stem cells to commit to the muscle repair
or to remain a stem cell depends upon patterns of gene expression, a process regulated at
the epigenetic level. Indeed, it is well accepted that dynamic changes in epigenetic …