On the structure and functions of gelatinase B/matrix metalloproteinase-9 in neuroinflammation
J Vandooren, J Van Damme, G Opdenakker - Progress in brain research, 2014 - Elsevier
The blood–brain barrier (BBB) is a specific structure that is composed of two basement
membranes (BMs) and that contributes to the control of neuroinflammation. As long as the
BBB is intact, extravasated leukocytes may accumulate between two BMs, generating
vascular cuffs. Specific matrix metalloproteinases, MMP-2 and MMP-9, have been shown to
cleave BBB beta-dystroglycan and to disintegrate thereby the parenchymal BM, resulting in
encephalomyelitis. This knowledge has been added to the molecular basis of the REGA …
membranes (BMs) and that contributes to the control of neuroinflammation. As long as the
BBB is intact, extravasated leukocytes may accumulate between two BMs, generating
vascular cuffs. Specific matrix metalloproteinases, MMP-2 and MMP-9, have been shown to
cleave BBB beta-dystroglycan and to disintegrate thereby the parenchymal BM, resulting in
encephalomyelitis. This knowledge has been added to the molecular basis of the REGA …