Effect of intra-articular triamcinolone vs saline on knee cartilage volume and pain in patients with knee osteoarthritis: a randomized clinical trial
TE McAlindon, MP LaValley, WF Harvey, LL Price… - Jama, 2017 - jamanetwork.com
Importance Synovitis is common and is associated with progression of structural
characteristics of knee osteoarthritis. Intra-articular corticosteroids could reduce cartilage
damage associated with synovitis but might have adverse effects on cartilage and
periarticular bone. Objective To determine the effects of intra-articular injection of 40 mg of
triamcinolone acetonide every 3 months on progression of cartilage loss and knee pain.
Design, Setting, and Participants Two-year, randomized, placebo-controlled, double-blind …
characteristics of knee osteoarthritis. Intra-articular corticosteroids could reduce cartilage
damage associated with synovitis but might have adverse effects on cartilage and
periarticular bone. Objective To determine the effects of intra-articular injection of 40 mg of
triamcinolone acetonide every 3 months on progression of cartilage loss and knee pain.
Design, Setting, and Participants Two-year, randomized, placebo-controlled, double-blind …