[HTML][HTML] Conventional CD4+ T cells regulate IL-22-producing intestinal innate lymphoid cells
LL Korn, HL Thomas, HG Hubbeling, SP Spencer… - Mucosal …, 2014 - Elsevier
The innate and adaptive immune systems in the intestine cooperate to maintain the integrity
of the intestinal barrier and to regulate the composition of the resident microbiota. However,
little is known about the crosstalk between the innate and adaptive immune systems that
contribute to this homeostasis. We find that CD4+ T cells regulate the number and function of
barrier-protective innate lymphoid cells (ILCs), as well as production of antimicrobial
peptides (AMPs), Reg3γ and Reg3β. RAG1−/− mice lacking T and B cells had elevated ILC …
of the intestinal barrier and to regulate the composition of the resident microbiota. However,
little is known about the crosstalk between the innate and adaptive immune systems that
contribute to this homeostasis. We find that CD4+ T cells regulate the number and function of
barrier-protective innate lymphoid cells (ILCs), as well as production of antimicrobial
peptides (AMPs), Reg3γ and Reg3β. RAG1−/− mice lacking T and B cells had elevated ILC …