Developmental origins of murine γδ T‐cell subsets

N Sumaria, S Martin, DJ Pennington - Immunology, 2019 - Wiley Online Library
N Sumaria, S Martin, DJ Pennington
Immunology, 2019Wiley Online Library
Murine γδ T cells display diverse responses to pathogens and tumours through early
provision of pro‐inflammatory cytokines such as interleukin‐17A (IL‐17) and interferon‐γ
(IFN‐γ). Although it is now clear that acquisition of these cytokine‐secreting effector fates is
to a great extent developmentally pre‐programmed in the thymus, the stages through which
γδ progenitor cells transition, and the underlying mechanistic processes that govern these
commitment events, are still largely unclear. Here, we review recent progress in the field …
Summary
Murine γδ T cells display diverse responses to pathogens and tumours through early provision of pro‐inflammatory cytokines such as interleukin‐17A (IL‐17) and interferon‐γ (IFN‐γ). Although it is now clear that acquisition of these cytokine‐secreting effector fates is to a great extent developmentally pre‐programmed in the thymus, the stages through which γδ progenitor cells transition, and the underlying mechanistic processes that govern these commitment events, are still largely unclear. Here, we review recent progress in the field, with particular consideration of how TCR‐γδ signalling impacts on developmental programmes initiated before TCR‐γδ expression.
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