Long-term behavioral change as a result of acute ethanol exposure in zebrafish: Evidence for a role for sonic hedgehog but not retinoic acid signaling
DF Burton, C Zhang, O Boa-Amponsem… - Neurotoxicology and …, 2017 - Elsevier
Background Developmental exposure to ethanol is recognized to produce long-term
neurobehavioral impairment in multiple animal models. However, the molecular
mechanisms underlying these deficits remain poorly understood. The present study was
undertaken to ascertain whether two well-characterized targets of prenatal alcohol
exposure, sonic hedgehog (Shh) and retinoic acid (RA), that induce the hallmark
morphological phenotypes of fetal alcohol spectrum disorders (FASD), are involved in the …
neurobehavioral impairment in multiple animal models. However, the molecular
mechanisms underlying these deficits remain poorly understood. The present study was
undertaken to ascertain whether two well-characterized targets of prenatal alcohol
exposure, sonic hedgehog (Shh) and retinoic acid (RA), that induce the hallmark
morphological phenotypes of fetal alcohol spectrum disorders (FASD), are involved in the …