Prenatal ethanol exposure enhances the susceptibility to metabolic syndrome in offspring rats by HPA axis-associated neuroendocrine metabolic programming
LP Xia, L Shen, H Kou, BJ Zhang, L Zhang, Y Wu, XJ Li… - Toxicology letters, 2014 - Elsevier
Objective The present study was designed to demonstrate that prenatal ethanol exposure
(PEE) could enhance the susceptibility of high-fat diet-induced metabolic syndrome (MS) in
adult male offspring via a hypothalamic–pituitary–adrenal (HPA) axis-associated
neuroendocrine metabolic programmed mechanism. Methods Pregnant Wistar rats were
intragastricly administrated ethanol 4 g/kg· d from gestational day 11 until term delivery. All
male offspring were fed with high-fat diet after weaning, exposed to an unpredictable chronic …
(PEE) could enhance the susceptibility of high-fat diet-induced metabolic syndrome (MS) in
adult male offspring via a hypothalamic–pituitary–adrenal (HPA) axis-associated
neuroendocrine metabolic programmed mechanism. Methods Pregnant Wistar rats were
intragastricly administrated ethanol 4 g/kg· d from gestational day 11 until term delivery. All
male offspring were fed with high-fat diet after weaning, exposed to an unpredictable chronic …