Phagocyte impotence caused by an invasive bacterial adenylate cyclase
DL Confer, JW Eaton - Science, 1982 - science.org
DL Confer, JW Eaton
Science, 1982•science.orgFor unknown reasons, humans infected with the bacterium Bordetella pertussis are
exceptionally vulnerable to secondary infections. Bordetella species elaborate a soluble,
heat-stable, and highly active adenylate cyclase. This enzyme is internalized by phagocytic
cells and catalyzes the unregulated formation of adenosine 3′, 5′-monophosphate (cyclic
AMP), thereby disrupting normal cellular function. This unusual phenomenon may explain
Bordetella-induced aphylaxis and may prove to be useful for investigating a variety of cyclic …
exceptionally vulnerable to secondary infections. Bordetella species elaborate a soluble,
heat-stable, and highly active adenylate cyclase. This enzyme is internalized by phagocytic
cells and catalyzes the unregulated formation of adenosine 3′, 5′-monophosphate (cyclic
AMP), thereby disrupting normal cellular function. This unusual phenomenon may explain
Bordetella-induced aphylaxis and may prove to be useful for investigating a variety of cyclic …
For unknown reasons, humans infected with the bacterium Bordetella pertussis are exceptionally vulnerable to secondary infections. Bordetella species elaborate a soluble, heat-stable, and highly active adenylate cyclase. This enzyme is internalized by phagocytic cells and catalyzes the unregulated formation of adenosine 3′,5′-monophosphate (cyclic AMP), thereby disrupting normal cellular function. This unusual phenomenon may explain Bordetella-induced aphylaxis and may prove to be useful for investigating a variety of cyclic AMP-governed processes.
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