[HTML][HTML] Activation of C3a receptor is required in cigarette smoke-mediated emphysema
Exposure to cigarette smoke can initiate sterile inflammatory responses in the lung and
activate myeloid dendritic cells (mDCs) that induce differentiation of T helper type 1 (Th1)
and Th17 cells in the emphysematous lungs. Consumption of complement proteins
increases in acute inflammation, but the contribution of complement protein 3 (C3) to chronic
cigarette smoke-induced immune responses in the lung is not clear. Here, we show that
following chronic exposure to cigarette smoke, C3-deficient (C3−/−) mice develop less …
activate myeloid dendritic cells (mDCs) that induce differentiation of T helper type 1 (Th1)
and Th17 cells in the emphysematous lungs. Consumption of complement proteins
increases in acute inflammation, but the contribution of complement protein 3 (C3) to chronic
cigarette smoke-induced immune responses in the lung is not clear. Here, we show that
following chronic exposure to cigarette smoke, C3-deficient (C3−/−) mice develop less …