Sarcopenia and osteopenia are two common components of the frailty syndrome that may
share a common underlying mechanism. Since frailty has been associated with increased
fat infiltration in muscle and bone, we hypothesized that lamin A/C, a protein of the nuclear
envelope that regulates adipose differentiation, could be associated with the
pathophysiology of both osteo and sarcopenia in the frailty syndrome. Four-week-old lamin
A/C null (Lmna−/−), heterozygous (Lmna+/−) and wild type (WT) mice were sacrificed and …