Modulation of endothelial dysfunction and apoptosis: UVA1-mediated skin improvement in systemic sclerosis
F Breuckmann, M Stuecker, P Altmeyer… - Archives of dermatological …, 2004 - Springer
F Breuckmann, M Stuecker, P Altmeyer, A Kreuter
Archives of dermatological research, 2004•SpringerUVA1-mediated effects regarding vascular dysregulation as a primary pathogenetic factor of
systemic sclerosis skin lesions have so far not been investigated. Pre-and posttherapy skin
biopsies of four patients were evaluated immunohistochemically for angiostatic, angiogenic
and angioapoptotic features. Immunohistochemistry revealed a partial pretherapy loss of
endothelial CD31 and CD34 expression accompanied by a posttherapy increase of CD34+
cells. Simultaneously, VEGF and M30 CytoDEATH immunolabeling demonstrated UVA1 …
systemic sclerosis skin lesions have so far not been investigated. Pre-and posttherapy skin
biopsies of four patients were evaluated immunohistochemically for angiostatic, angiogenic
and angioapoptotic features. Immunohistochemistry revealed a partial pretherapy loss of
endothelial CD31 and CD34 expression accompanied by a posttherapy increase of CD34+
cells. Simultaneously, VEGF and M30 CytoDEATH immunolabeling demonstrated UVA1 …
Abstract
UVA1-mediated effects regarding vascular dysregulation as a primary pathogenetic factor of systemic sclerosis skin lesions have so far not been investigated. Pre- and posttherapy skin biopsies of four patients were evaluated immunohistochemically for angiostatic, angiogenic and angioapoptotic features. Immunohistochemistry revealed a partial pretherapy loss of endothelial CD31 and CD34 expression accompanied by a posttherapy increase of CD34+ cells. Simultaneously, VEGF and M30 CytoDEATH immunolabeling demonstrated UVA1-induced neovascularization and decreased endothelial apoptosis. Our results suggest that UVA1 irradiation exerts its positive effects by a modulation of endothelial regulation/transformation beside the proposed induction of T cell apoptosis and collagenases.
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