Expression of interleukin-4 in scleroderma skin specimens and scleroderma fibroblast cultures: potential role in fibrosis
V Salmon-Ehr, H Serpier, B Nawrocki… - Archives of …, 1996 - jamanetwork.com
Background: Scleroderma (systemic sclerosis) is a fibrotic disease characterized by an
uncontrolled tissular accumulation of collagen. Several cytokines have been implicated in
the fibroblast activation leading to fibrosis. For instance, we have previously demonstrated
that interleukin-4 (IL-4) is a potent activator of collagen synthesis in fibroblast cultures. In this
study, using immunocytochemical methods and in situ hybridization, we investigated the
expression of IL-4 in normal and scleroderma skin and fibroblast cultures. Observations …
uncontrolled tissular accumulation of collagen. Several cytokines have been implicated in
the fibroblast activation leading to fibrosis. For instance, we have previously demonstrated
that interleukin-4 (IL-4) is a potent activator of collagen synthesis in fibroblast cultures. In this
study, using immunocytochemical methods and in situ hybridization, we investigated the
expression of IL-4 in normal and scleroderma skin and fibroblast cultures. Observations …