[HTML][HTML] Regulation of RIPK3-and RHIM-dependent necroptosis by the proteasome
K Moriwaki, FKM Chan - Journal of Biological Chemistry, 2016 - ASBMB
Receptor-interacting protein kinase 3 (RIPK3) is a serine/threonine kinase with essential
function in necroptosis. The activity of RIPK3 is controlled by phosphorylation. Once
activated, RIPK3 phosphorylates and activates the downstream effector mixed lineage
kinase domain-like (MLKL) to induce necroptosis. In certain situations, RIPK3 has also been
shown to promote apoptosis or cytokine expression in a necroptosis and kinase-
independent manner. The ubiquitin-proteasome system is the major pathway for selective …
function in necroptosis. The activity of RIPK3 is controlled by phosphorylation. Once
activated, RIPK3 phosphorylates and activates the downstream effector mixed lineage
kinase domain-like (MLKL) to induce necroptosis. In certain situations, RIPK3 has also been
shown to promote apoptosis or cytokine expression in a necroptosis and kinase-
independent manner. The ubiquitin-proteasome system is the major pathway for selective …