Pathogenesis of hepatic encephalopathy: role of ammonia and systemic inflammation
DR Aldridge, EJ Tranah, DL Shawcross - Journal of clinical and …, 2015 - Elsevier
The syndrome we refer to as Hepatic Encephalopathy (HE) was first characterized by a team
of Nobel Prize winning physiologists led by Pavlov and Nencki at the Imperial Institute of
Experimental Medicine in Russia in the 1890's. This focused upon the key observation that
performing a portocaval shunt, which bypassed nitrogen-rich blood away from the liver,
induced elevated blood and brain ammonia concentrations in association with profound
neurobehavioral changes. There exists however a spectrum of metabolic encephalopathies …
of Nobel Prize winning physiologists led by Pavlov and Nencki at the Imperial Institute of
Experimental Medicine in Russia in the 1890's. This focused upon the key observation that
performing a portocaval shunt, which bypassed nitrogen-rich blood away from the liver,
induced elevated blood and brain ammonia concentrations in association with profound
neurobehavioral changes. There exists however a spectrum of metabolic encephalopathies …