From stem cell to erythroblast: regulation of red cell production at multiple levels by multiple hormones
H Lodish, J Flygare, S Chou - IUBMB life, 2010 - Wiley Online Library
H Lodish, J Flygare, S Chou
IUBMB life, 2010•Wiley Online LibraryThis article reviews the regulation of production of red blood cells at several levels:(1) the
ability of erythropoietin and adhesion to a fibronectin matrix to stimulate the rapid production
of red cells by inducing terminal proliferation and differentiation of committed erythroid CFU‐
E progenitors;(2) the regulated expansion of the pool of earlier BFU‐E erythroid progenitors
by glucocorticoids and other factors that occurs during chronic anemia or inflammation; and
(3) the expansion of thehematopoietic cell pool to produce more progenitors of all …
ability of erythropoietin and adhesion to a fibronectin matrix to stimulate the rapid production
of red cells by inducing terminal proliferation and differentiation of committed erythroid CFU‐
E progenitors;(2) the regulated expansion of the pool of earlier BFU‐E erythroid progenitors
by glucocorticoids and other factors that occurs during chronic anemia or inflammation; and
(3) the expansion of thehematopoietic cell pool to produce more progenitors of all …
Abstract
This article reviews the regulation of production of red blood cells at several levels: (1) the ability of erythropoietin and adhesion to a fibronectin matrix to stimulate the rapid production of red cells by inducing terminal proliferation and differentiation of committed erythroid CFU‐E progenitors; (2) the regulated expansion of the pool of earlier BFU‐E erythroid progenitors by glucocorticoids and other factors that occurs during chronic anemia or inflammation; and (3) the expansion of thehematopoietic cell pool to produce more progenitors of all hematopoietic lineages. © 2010 IUBMB IUBMB Life 62(7): 492–496, 2010
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