The regulation of liver regeneration by the plasmin/α2-antiplasmin system
K Okada, S Ueshima, M Imano, K Kataoka… - Journal of hepatology, 2004 - Elsevier
Background/Aims: The regeneration after liver injury is regulated by the release and
activation of several growth factors. The role of the plasmin/α2-antiplasmin (α2-AP) system in
liver regeneration was investigated. Methods: CCl4 was injected intraperitoneally into the
mice deficient (−/−) in fibrinolytic factors: α2-AP−/−, plasminogen (Plg)−/−, and Plg−/−· α2-
AP−/−, and wild-type (WT) mice. The liver tissue was examined for its microscopic
appearance, fibrinolytic activity, and fibronectin levels. Results: In the gene deficient and WT …
activation of several growth factors. The role of the plasmin/α2-antiplasmin (α2-AP) system in
liver regeneration was investigated. Methods: CCl4 was injected intraperitoneally into the
mice deficient (−/−) in fibrinolytic factors: α2-AP−/−, plasminogen (Plg)−/−, and Plg−/−· α2-
AP−/−, and wild-type (WT) mice. The liver tissue was examined for its microscopic
appearance, fibrinolytic activity, and fibronectin levels. Results: In the gene deficient and WT …