Importance of Connexin-43 based gap junction in cirrhosis and acute-on-chronic liver failure
V Balasubramaniyan, DK Dhar, AE Warner, WYV Li… - Journal of …, 2013 - Elsevier
BACKGROUND & AIMS: In cirrhosis, superimposed inflammation often culminates in acute-
on-chronic liver failure (ACLF) but the mechanism underlying this increased sensitivity is not
clear. Cx43 is a ubiquitous gap junction protein that allows transmission of signals between
cells at a much higher rate than the constitutively expressed gap junctions. The aims of the
study were to test the hypothesis that inflammation drives the increased expression of
hepatic Cx43 and to determine its role by Cx43 inhibition. METHODS: Four weeks after bile …
on-chronic liver failure (ACLF) but the mechanism underlying this increased sensitivity is not
clear. Cx43 is a ubiquitous gap junction protein that allows transmission of signals between
cells at a much higher rate than the constitutively expressed gap junctions. The aims of the
study were to test the hypothesis that inflammation drives the increased expression of
hepatic Cx43 and to determine its role by Cx43 inhibition. METHODS: Four weeks after bile …