[HTML][HTML] Death associated protein kinase 1 (DAPK1): a regulator of apoptosis and autophagy
Death-Associated Protein Kinase 1 (DAPK1) belongs to a family of five serine/threonine
(Ser/Thr) kinases that possess tumor suppressive function and also mediate a wide range of
cellular processes, including apoptosis and autophagy. The loss and gain-of–function of
DAPK1 is associated with various cancer and neurodegenerative diseases respectively. In
recent years, mechanistic studies have broadened our knowledge of the molecular
mechanisms involved in DAPK1-mediated autophagy/apoptosis. In the present review, we …
(Ser/Thr) kinases that possess tumor suppressive function and also mediate a wide range of
cellular processes, including apoptosis and autophagy. The loss and gain-of–function of
DAPK1 is associated with various cancer and neurodegenerative diseases respectively. In
recent years, mechanistic studies have broadened our knowledge of the molecular
mechanisms involved in DAPK1-mediated autophagy/apoptosis. In the present review, we …
Death-Associated Protein Kinase 1 (DAPK1) belongs to a family of five serine/threonine (Ser/Thr) kinases that possess tumor suppressive function and also mediate a wide range of cellular processes, including apoptosis and autophagy. The loss and gain-of–function of DAPK1 is associated with various cancer and neurodegenerative diseases respectively. In recent years, mechanistic studies have broadened our knowledge of the molecular mechanisms involved in DAPK1-mediated autophagy/apoptosis. In the present review, we have discussed the structural information and various cellular functions of DAPK1 in a comprehensive manner.
Frontiers