Regulation of cAMP by light and dopamine receptors is dysfunctional in photoreceptors of dystrophic retinal degeneration slow (rds) mice
I Nir, R Haque, PM Iuvone - Experimental eye research, 2001 - Elsevier
cAMP levels in dark and light were studied in dystrophic retinal degeneration slow (rds)
mice, which carry a mutation in the rds/peripherin gene. cAMP levels were measured in vivo,
in freshly isolated retinas, and in vitro in the presence of glutamate, which confines light
modulation to photoreceptors. Experiments were conducted on young animals, when
significant numbers of viable photoreceptor cells are present. In vivo levels of cAMP are
higher in illuminated rds/rds retinas than levels measured in normal BALB/c retinas. Light …
mice, which carry a mutation in the rds/peripherin gene. cAMP levels were measured in vivo,
in freshly isolated retinas, and in vitro in the presence of glutamate, which confines light
modulation to photoreceptors. Experiments were conducted on young animals, when
significant numbers of viable photoreceptor cells are present. In vivo levels of cAMP are
higher in illuminated rds/rds retinas than levels measured in normal BALB/c retinas. Light …