Cyclic nucleotide content and phosphodiesterase activity in the rds mouse 020/A) retina
S Sanyal, R Fletcher, YP Liu, G Aguirre… - Experimental eye …, 1984 - Elsevier
Cyclic nucleotide metabolism was examined in the retina and in the retinal pigment
epithelium (RPE)-choroid complex of the rds mouse (020/A), a mutant in which discrete
photoreceptor outer segment disc structures fail to develop. In retinas of both rds and control
(Balb/c) mice, cyclic AMP levels peak at 10–15 days (20–25 pmol mg− 1 protein). The level
drops to about 10 pmol mg− 1 at about one month in normal retinas but remains high in
affected retinas. Cyclic GMP levels increase five-fold in Balb/c retinas as ROS develop …
epithelium (RPE)-choroid complex of the rds mouse (020/A), a mutant in which discrete
photoreceptor outer segment disc structures fail to develop. In retinas of both rds and control
(Balb/c) mice, cyclic AMP levels peak at 10–15 days (20–25 pmol mg− 1 protein). The level
drops to about 10 pmol mg− 1 at about one month in normal retinas but remains high in
affected retinas. Cyclic GMP levels increase five-fold in Balb/c retinas as ROS develop …
