[HTML][HTML] Liver-specific gene inactivation of the transcription factor ATF4 alleviates alcoholic liver steatosis in mice
Although numerous biological functions of the activating transcription factor 4 (ATF4) have
been identified, a direct effect of ATF4 on alcoholic liver steatosis has not been described
previously. The aim of our current study is to investigate the role of ATF4 in alcoholic liver
steatosis and elucidate the underlying mechanisms. Here, we showed that the expression of
ATF4 is induced by ethanol in hepatocytes in vitro and in vivo, and liver-specific ATF4 knock-
out mice are resistant to ethanol-induced liver steatosis, associated with stimulated hepatic …
been identified, a direct effect of ATF4 on alcoholic liver steatosis has not been described
previously. The aim of our current study is to investigate the role of ATF4 in alcoholic liver
steatosis and elucidate the underlying mechanisms. Here, we showed that the expression of
ATF4 is induced by ethanol in hepatocytes in vitro and in vivo, and liver-specific ATF4 knock-
out mice are resistant to ethanol-induced liver steatosis, associated with stimulated hepatic …