Role of thyroid hormones in the modification of diet-induced thermogenesis by propranolol
DL Ingram, MJ Dauncey - Hormone and metabolic research, 1986 - thieme-connect.com
DL Ingram, MJ Dauncey
Hormone and metabolic research, 1986•thieme-connect.comThe effect of thyroid hormones on the reduction in resting metabolic rate by the β-blocker
propranolol has been investigated in young pigs. Oxygen consumption was measured 12 to
20 hr after the last meal in euthyroid and hypothyroid animals on a high or low level of
energy intake. The increase in resting metabolic rate in animals on the high energy intake
was reduced by propranolol in the euthyroid controls but not in those animals made
hypothyroid by methimazole. Thus at least part of the action of propranolol to decrease diet …
propranolol has been investigated in young pigs. Oxygen consumption was measured 12 to
20 hr after the last meal in euthyroid and hypothyroid animals on a high or low level of
energy intake. The increase in resting metabolic rate in animals on the high energy intake
was reduced by propranolol in the euthyroid controls but not in those animals made
hypothyroid by methimazole. Thus at least part of the action of propranolol to decrease diet …
Summary
The effect of thyroid hormones on the reduction in resting metabolic rate by the β-blocker propranolol has been investigated in young pigs. Oxygen consumption was measured 12 to 20 hr after the last meal in euthyroid and hypothyroid animals on a high or low level of energy intake. The increase in resting metabolic rate in animals on the high energy intake was reduced by propranolol in the euthyroid controls but not in those animals made hypothyroid by methimazole. Thus at least part of the action of propranolol to decrease diet-induced thermogenesis depends on its interaction with thyroid hormones.
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