[HTML][HTML] Human αβ and γδ T cells in skin immunity and disease

MS Cruz, A Diamond, A Russell… - Frontiers in …, 2018 - frontiersin.org
MS Cruz, A Diamond, A Russell, JM Jameson
Frontiers in immunology, 2018frontiersin.org
γδ T lymphocytes maintain skin homeostasis by balancing keratinocyte differentiation and
proliferation with the destruction of infected or malignant cells. An imbalance in skin-resident
T cell function can aggravate skin-related autoimmune diseases, impede tumor eradication,
or disrupt proper wound healing. Much of the published work on human skin T cells
attributes T cell function in the skin to αβ T cells, while γδ T cells are an often overlooked
participant. This review details the roles played by both αβ and γδ T cells in healthy human …
γδ T lymphocytes maintain skin homeostasis by balancing keratinocyte differentiation and proliferation with the destruction of infected or malignant cells. An imbalance in skin-resident T cell function can aggravate skin-related autoimmune diseases, impede tumor eradication, or disrupt proper wound healing. Much of the published work on human skin T cells attributes T cell function in the skin to αβ T cells, while γδ T cells are an often overlooked participant. This review details the roles played by both αβ and γδ T cells in healthy human skin and then focuses on their roles in skin diseases, such as psoriasis and alopecia areata. Understanding the contribution of skin-resident and skin-infiltrating T cell populations and cross-talk with other immune cells is leading to the development of novel therapeutics for patients. However, there is still much to be learned in order to effectively modulate T cell function and maintain healthy skin homeostasis.
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