[HTML][HTML] Pancreatic triglyceride lipase deficiency minimally affects dietary fat absorption but dramatically decreases dietary cholesterol absorption in mice
KW Huggins, LM Camarota, PN Howles… - Journal of Biological …, 2003 - ASBMB
This study generated pancreatic triglyceride lipase (PTL)-null mice to test the hypothesis that
PTL-mediated hydrolysis of dietary triglyceride is necessary for efficient dietary cholesterol
absorption. The PTL–/–mice grew normally and displayed similar body weight as their
PTL+/+ littermates. Plasma lipid levels between animals of various PTL genotypes were
similar when they were maintained on either a basal low fat diet or a western-type high
fat/high cholesterol diet. Although the lack of a functional PTL delayed fat absorption during …
PTL-mediated hydrolysis of dietary triglyceride is necessary for efficient dietary cholesterol
absorption. The PTL–/–mice grew normally and displayed similar body weight as their
PTL+/+ littermates. Plasma lipid levels between animals of various PTL genotypes were
similar when they were maintained on either a basal low fat diet or a western-type high
fat/high cholesterol diet. Although the lack of a functional PTL delayed fat absorption during …