Interleukin-1β inhibits long-term potentiation in the CA3 region of mouse hippocampal slices
H Katsuki, S Nakai, Y Hirai, K Akaji, Y Kiso… - European journal of …, 1990 - Elsevier
H Katsuki, S Nakai, Y Hirai, K Akaji, Y Kiso, M Satoh
European journal of pharmacology, 1990•ElsevierThe effect of recombinant human interleukin-1β (IL-1β) on long-term potentiation (LTP) in the
mossy fiber-CA3 pathway of mouse hippocampal slice preparations was investigated. IL-1β
significantly inhibited LTP in concentrations as low as 2.9 pM (50 pg/ml). This effect of IL-1β
was blocked by concurrent application of 100 nM Lys-D-Pro-Thr, a tripeptide analogue of IL-
1β. This is the first evidence that IL-1β can regulate LTP of synaptic transmission in the
hippocampus.
mossy fiber-CA3 pathway of mouse hippocampal slice preparations was investigated. IL-1β
significantly inhibited LTP in concentrations as low as 2.9 pM (50 pg/ml). This effect of IL-1β
was blocked by concurrent application of 100 nM Lys-D-Pro-Thr, a tripeptide analogue of IL-
1β. This is the first evidence that IL-1β can regulate LTP of synaptic transmission in the
hippocampus.
Abstract
The effect of recombinant human interleukin-1β (IL-1β) on long-term potentiation (LTP) in the mossy fiber-CA3 pathway of mouse hippocampal slice preparations was investigated. IL-1β significantly inhibited LTP in concentrations as low as 2.9 pM (50 pg/ml). This effect of IL-1β was blocked by concurrent application of 100 nM Lys-D-Pro-Thr, a tripeptide analogue of IL-1β. This is the first evidence that IL-1β can regulate LTP of synaptic transmission in the hippocampus.
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