Pro-inflammatory cytokines and their effects in the dentate gyrus

M Pickering, JJ O'Connor - Progress in brain research, 2007 - Elsevier
The older notion of a central nervous system existing in essential isolation from the immune
system has changed dramatically in recent years as the body of evidence relating to the
interactions between these two systems has grown. Here we address the role of a particular
subset of immune modulatory molecules, the pro-inflammatory cytokines, in regulating
neuronal function and viability in the dentate gyrus of the hippocampus. These inflammatory
mediators are known to be elevated in many neuropathological conditions, such as …