Preserved proinsulin secretion in long-standing type 1 diabetes
DW Steenkamp, JM Cacicedo, A Sahin-Efe, C Sullivan… - Endocrine Practice, 2017 - Elsevier
Objective: Recent literature has reported preserved residual beta-cell function (C-peptide
“microsecretion”) in many individuals with long-standing type 1 diabetes (T1D). However,
the concentrations of detectable insulin/C-peptide in the serum are usually very low, and
beta-cell mass is typically negligible. Proinsulin is measurable in the early years after
diagnosis, consistent with the presence of residual functioning beta cells. However,
individuals are not expected to secrete significant amounts of proinsulin beyond the early …
“microsecretion”) in many individuals with long-standing type 1 diabetes (T1D). However,
the concentrations of detectable insulin/C-peptide in the serum are usually very low, and
beta-cell mass is typically negligible. Proinsulin is measurable in the early years after
diagnosis, consistent with the presence of residual functioning beta cells. However,
individuals are not expected to secrete significant amounts of proinsulin beyond the early …